Prognostic implication of residual inflammatory risk according to disease status in patients treated with percutaneous coronary intervention

Abstract Background Compared with stable angina, acute myocardial infarction (AMI) phenotype is related the elevated inflammatory activity. However, time-dependent change of level and its prognostic implication has not been fully understood according to disease entity. Methods We enrolled total 4,263 patients who underwent percutaneous coronary intervention (PCI) serial measurement high-sensitivity C-reactive protein (hsCRP) at on-admission 1-month post-PCI. The risks MACE (a composite death, MI or stroke), major bleeding were evaluated up 4 years after procedure. Results non-AMI group (n=1,887), AMI (n=2,376) showed significant decrease hs-CRP during 1 month (∇0.5 vs. ∇0.1 mg/L; P<0.001). value still was higher in than (median: 1.0 0.9 P=0.001). During follow-up, high low risk (upper lower tertile hs-CRP) significantly associated increased rate (HR: 7.66; 95% CI: 2.29–25.59; P<0.001), but 0.74; 0.12–4.40; P=0.736). From 4-years, greater compared those risk, both 2.40; 1.73–3.45; P<0.001) 2.67; 1.80–3.94; groups. Conclusion In PCI-treated patients, presented values activity early phase, combined appeared similar across entity late phase. This result may support that clinical benefit post-PCI anti-inflammatory treatment would be constant regardless stabilized Funding Acknowledgement Type funding sources: None.